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CAS No.: 426-13-1

氟米龙 Catalog No. CSN24130

Synonyms: Oxylone;Allergan;Alcon

Fluorometholone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors^[1]. Fluorometholone is a widely used anti-inflammatory ophthalmic formulation, which elicits a lower ocular hypertensive response than other glucocorticoid medications^[2].
参考文献

[1] Taniguchi J, Sharma A. Fluorometholone modulates gene expression of ocular surface mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088
[2] Baba K, Hashida N, Tujikawa M, Quantock AJ, Nishida K. The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes. Int J Pharm. 2021 Jan 5;592:120067

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6563 mL
- 13.2816 mL
- 26.5631 mL
- 5 mM
- 0.5313 mL
- 2.6563 mL
- 5.3126 mL
- 10 mM
- 0.2656 mL
- 1.3282 mL
- 2.6563 mL

技术信息

CAS号

426-13-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H29FO4

运输

蓝冰

分子量

376.46

别名

Oxylone;Allergan;Alcon;UNII9I50C3I3OK;NSC 47438;U-8614;NSC-33001;氟米龙

溶解度

DMSO	74.0 mg/mL (196.6 mM)
Water	Insoluble
Ethanol	5.0 mg/mL (13.3 mM)

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